Physiological systems maintain homeostasis by the integration of wide ranges of endogenous and exogenous signals. The physiological set-points and the degree of the integration of input signals is possible to express as variability, entropy and predictability.
As physiologist, I'm interested in the integration of time by the cardiovascular system. For this purpose, I'm collecting in vivo physiological data with telemetry. For a better understanding of the integration of the input information, I'm doing in silico experiments (modeling) in collaborations with mathematicians.
Shifts in the light-dark cycle increase unpredictability of the cardiovascular system
2017; Autonomic Neuroscience: Basic and Clinical; Molcan L, Zeman M.
Light at night increases blood pressure response to norepinephrine in hypertensive rats
2017; Acta Physiologica; Molcan L, Sutovska H, Zeman M.
Influences of phase delay shifts of light and food restriction on blood pressure and heart rate in telemetry monitored rats
2016; Biological Rhythm Research; Molcan L, Vesela A, Zeman M.
Decreased emotional reactivity of rats exposed to repeated phase shifts of light-dark cycle
2016; Physiology and behavior; Okuliarova M, Molcan L, Zeman M.
Prenatal hypoxia in rats increased blood pressure and sympathetic drive of the adult offspring
2016; Hypertension Research; Svitok P, Molcan L, Stebelova K, Vesela A, Sedlackova N, Ujhazy E, Mach M, Zeman M.
Endocrine and cardiovascular rhythms differentially adapt to chronic phase-delay shifts in rats
2016; Chronobiology International; Zeman M, Molcan L, Herichova I, Okuliarova M.
Chronic phase advance shifts desynchronize endocrine rhythms and enhance responsivity of the cardiovascular system to norepinephrine in rats
2016; Proceedings of The Physiological Society; Zeman M, Okuliarova M, Molcan L.
Increased salt intake during early ontogenesis lead to development of arterial hypertension in salt-resistant Wistar rats
2015; Clinical and Experimental Hypertension; Svitok P, Molcan L, Vesela A, Kruzliak P, Moravcik R, Zeman M.
The influence of indoor lighting with low blue light dose on urine 6-sulphatoxymelatonin concentrations and sleep efficiency of healthy volunteers
2015; Biological Rhythm Research; Stebelova K, Molcan L, Okuliarova M, Hanuliak P, Hartman P, Hraska J, Zeman M.
Different expression and localization pattern of MT1 melatonin receptor between conduit and resistant arteries can be involved in positive effects of melatonin on blood pressure control
2014; Acta Physiologica; Molcan L, Svitok P, Stebelova K, Vesela A, Ellinger I, Zeman M.
Repeated phase shifts in the lighting regimen change the blood pressure response to norepinephrine stimulation in rats
2014; Physiological Research; Molcan L, Vesela A, Zeman M.
Exposure of pregnant rats to angiotensin 2 leads to an increase in blood pressure in their adult male offspring
2014; Acta Physiologica; Svitok P, Molcan L, Stefanik P, Vesela A, Zeman M.
Expression of hyperoxic bradycardia during hyperbaric exposure in rats prenatally exposed to hypoxia
2014; The FASEB Journal; Rozloznik M, Molcan L, Svitok P, Balestra C, Zeman M.
Different effects of phase advance and delay in rotating light-dark regimens on clock and natriuretic peptide gene expression in the rat heart
2014; Physiological Research; Herichova I, Ambrusova J, Molcan L, Vesela A, Svitok P, Zeman M.
The long-term effects of phase advance shifts of photoperiod on cardiovascular parameters as measured by radiotelemetry in rats
2013; Physiological measurement; Molcan L, Teplan M, Vesela A, Zeman M.
Localization of melatonin receptors in the adventitia of the rat aorta
2012; Vascular Pharmacology; Zeman M, Schepelmann M, Molcan L, Uhrova H, Ellinger I.
The presence and localization of melatonin receptors in the rat aorta
2011; Cellular and molecular neurobiology; Schepelmann M, Molcan L, Uhrova H, Zeman M, Ellinger I.
Radiotelemetry measurement of heart rate, blood pressure and locomotory activity of rats in physiological experiment
2009; Slovak J. Anim. Sci; Molcan L, Vesela A, Zeman M.